A new study from the Translational Genomics Research Institute has found that a family’s socioeconomic status (SES) may influence the composition of their children’s gut microbiome. The research has been published in the ‘Microorganisms Journal’.
SES includes economic resources such as education, income and occupation, and is reflected in living conditions, nutrition and psychosocial stress, according to the study, which focused on education levels mothers and fathers. DNA and nucleic acid samples from a racially diverse group of 588 children, aged 1 month to 15 years, revealed that environmental factors such as SES can influence the health of individuals throughout their lives. life, potentially influencing measures such as blood pressure, height, weight, diabetes, obesity and even attention deficit/hyperactivity disorder (ADHD).
The gut microbiota plays an important role in a wide range of bodily functions, including the immune system, metabolic and inflammatory processes, and the central nervous system. While previous studies have looked at how SES may affect the gut microbiome in adults, this is one of the first such examinations in young children, according to the study.
“These findings may have important implications for understanding how interventions in childhood might help prevent the eventual impact of SES on microbiome diversity and later health,” said Candace Lewis, PhD, postdoctoral fellow at the division. neurogenomics of TGen and lead author of the study. . “Our results demonstrate that modifiable environmental factors, such as SES, can influence the composition of the gut microbiome at an early age,” Lewis added.
Human DNA samples were taken from saliva. Microbial nucleic acid samples were extracted from stool. Investigators tested and classified an abundance of gut microbes, including Anaerostipes, Bacteroides, Eubacterium, Faecalibacterium, and Lachnospiraceae. Parents with more years of education had children who scored higher on a “latent microbiome factor“, defined as a greater abundance of Anaerostipes, Eubacterium, Faecalibacterium and Lachnospiraceae and a higher low abundance of Bacteroides. Faecalibacterium, considered a key biomarker of a healthy gut, produces butyrate, which is an energy source that plays a major role in gut physiology and has several health benefits including protection against pathogens, modulating the immune system and reducing cancer progression. .
“Faecalibacterium abundance may be a biological pathway in which early environmental influences shape disease susceptibility across the lifespan,” the study says. Other factors taken into account in the study were age, sex, exposure to antibiotics and even the type of birth (whether the child was born vaginally or by cesarean section).
“These findings are important, as our understanding of gut microbiome influences on health continues to expand,” said Sarah Highlander, PhD, research professor in TGen’s Pathogen and Microbiome Division and one of the authors of the study. ‘study. “This study tests associations between family SES with relative abundance of microbiota type and diversity in infants and children while controlling for potential genetic associations,” she added.
Contributors to this study: Arizona State University; Wellesley College; Hasbro Children’s Hospital; Brown University; and Maternal, Newborn & Child Health Discovery & Tools, part of the Bill and Melinda Gates Foundation. (ANI)
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