Children’s socioeconomic status may impact microorganisms in the digestive tract, study finds

January 10, 2022 12:43 PM STI

Washington [US]Jan. 10 (ANI): A new study by the Translational Genomics Research Institute has found that a family’s socioeconomic status (SES) may influence the makeup of their children’s gut microbiome.
The research has been published in the ‘Microorganisms Journal’.
SES includes economic resources such as education, income and occupation, and is reflected in living conditions, nutrition and psychosocial stress, according to the study, which focused on education levels. mothers and fathers.
DNA and nucleic acid samples from a racially diverse group of 588 children, aged 1 month to 15 years, found that environmental factors such as SES could influence the health of individuals throughout their life. life, potentially influencing measures such as blood pressure, height, weight, diabetes, obesity and even attention deficit hyperactivity disorder (ADHD).
The gut microbiota plays an important role in a wide range of bodily functions, including the immune system, metabolic and inflammatory processes, and the central nervous system.
While previous studies have looked at how SES can affect the gut microbiome in adults, this is one of the first such exams in young children, according to the study.
“These findings may have important implications for understanding how interventions in childhood might help prevent the possible impact of SES on microbiome diversity and subsequent health,” said Candace Lewis, PhD, postdoctoral researcher in the division. Neurogenomics of TGen and lead author of the study. .

“Our results demonstrate that modifiable environmental factors, such as SES, can influence the composition of the gut microbiome at an early age,” added Lewis.
Human DNA samples were taken from the saliva. Samples of microbial nucleic acids were extracted from the stool. Researchers tested and classified an abundance of gut microbes, including Anaerostipes, Bacteroides, Eubacterium, Faecalibacterium, and Lachnospiraceae. Parents with more years of education had children who scored higher on a “latent microbiome factor“, defined as higher abundance of Anaerostipes, Eubacterium, Faecalibacterium and Lachnospiraceae and abundance lower of Bacteroides.
Faecalibacterium, considered a key biomarker of a healthy gut, produces butyrate, which is an energy source that plays a major role in intestinal physiology and has several beneficial health effects, including protection against pathogens, modulation of the immune system and reduction of cancer progression.
“Faecalibacterium abundance may be a biological pathway in which early environmental influences shape vulnerability to disease throughout life,” the study said.
Other factors considered in the study were age, gender, exposure to antibiotics, and even type of birth (whether the child was born vaginally or by Caesarean section).
“These findings are important as our understanding of the influences of the gut microbiome on health continues to expand,” said Sarah Highlander, PhD, Research Professor in the Pathogen and Microbiome Division at TGen and one of the authors of the ‘study.
“This study tests associations between familial SES with relative abundance of microbiota type and diversity in infants and children while monitoring for potential genetic associations,” she added.
The following people contributed to this study: Arizona State University; Wellesley College; Hasbro Children’s Hospital; Brown University; and Maternal, Newborn and Child Health Discovery and Tools, part of the Bill and Melinda Gates Foundation. (ANI)